![]() ![]() This further suggests a limited role for cycA in DCS sensitivity. coli K-12 gcvB mutant strains failed to demonstrate a change in DCS sensitivity when grown in LB. coli K-12 cycA expression when grown in LB. The small RNA GvcB acts as a negative regulator of E. These data suggest that cycA does not participate in DCS sensitivity when strains are grown in a non-minimal medium. However, the cycA mutants exhibit no change in DCS sensitivity compared to their parental strains when grown in LB (CFT073 and K-12) or human urine (CFT073 only). coli K-12 cycA and CFT073 cycA mutant strains display increased DCS resistance when grown in minimal medium. When Escherichia coli K-12 or CFT073 is grown in minimal glucose or glycerol medium, CycA transports DCS into the cell. D-Cycloserine (DCS) is a broad-spectrum antibiotic that inhibits d-alanine ligase and alanine racemase activity. ![]()
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